The injury bug reared its ugly head yet again in the Steelers third preseason game, as rookie guard David DeCastro suffered a knee injury on Pittsburgh's second possession of the game and had to be carted into the locker room. Running game Isaac Redman had to temporarily leave the field with a stinger, but quickly returned to action. Defensive end Brett Keisel also left the game with what Mike Tomlin described as a mild high ankle sprain.
Buffalo scored first on its second possession thanks to a 49 scoring drive that concluded with a Fred Jackson one yard touchdown run.
Pittsburgh struggled on offense in the first quarter, going two and out on its first two possessions. However, Ziggy Hood recovered a fumble at the Buffalo 18 yard line, and Pittsburgh capitalized with a two yard touchdown run by Redman to make it 7-7 midway through the second quarter.
The Steelers offense finally came to life late in the second quarter and went on a 98 yard scoring drive that included a 33 yard pass from Ben Roethlisberger to Jonathan Dwyer that got Pittsburgh out of the shadow of its own end zone, and concluded with a six yard touchdown pass from Roethlisberger to Antonio Brown to make it 14-7 at the half.