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This week's start/sit will focus less on potential matchups and more on just which players you should start or bench. We try to use not so obvious players to start such as "Antonio Brown vs. San Francisco" or "Marshawn Lynch @ Green Bay" beause those are the players you're going to start anyway. Instead, we try to find the more diffcult matchups for you to look at here.
Quarterbacks:
| Players to Start | Players to Sit | |
| 1 | Joe Flacco @ Oakland | Alex Smith vs. Denver |
| 2 | Drew Brees vs. Tampa Bay | Derek Carr vs. Baltimore |
| 3 | Cam Newton vs. Houston | Eli Manning vs. Atlanta |
| 4 | Tyrod Taylor vs. New England | Kirk Cousins vs. St. Louis |
| 5 | Marcus Mariota @ Cleveland | Jay Cutler vs. Arizona |
Oakland was torched last week by Andy Dalton, so look for Flacco to connect on some big plays to his players and get around three touchdowns this week. While Drew Brees has fallen back from the elite of the elite, if you have a tough choice between him and Tom Brady or Peyton Manning this week, pick Brees. Though Cleveland was tough for quarterbacks last season, Mariota could be a great start this week after we saw Ryan Fitzpatrick do well against Cleveland to start the season.
Alex Smith had a strong start to the season, but he's going up against a tough Broncos defense that will make him earn every yard and he will have to hope for another huge game from Travis Kelce. The Atlanta Falcons were able to slow down Sam Bradford and the Philadelphia Eagles long enough to get the win last week, look for Eli to continue his struggles against them this week.
Running Backs:
| Players to Start | Players to Sit | |
| 1 | Tevin Coleman @ New York Giants | Alfred Morris vs. St. Louis |
| 2 | Chris Ivory @ Indianapolis | CJ Anderson @ Kansas City |
| 3 | Giovani Bernard vs. San Diego | Alfred Blue @ Carolina |
| 4 | DeAngelo Williams vs. San Francisco | Frank Gore vs. New York Jets |
| 5 | Bishop Sankey @ Cleveland | Latavius Murray vs. Baltimore |
Tevin Coleman had a really strong start to the season against the Philadelphia Eagles last week, give him a shot this week to be your playmaker. While Jeremy Hill is always an obvious start, you should really consider playing his teammate Giovani Bernard this week against the San Diego Chargers. He put up solid numbers last week and the Chargers surrendered over 90 yards and a touchdown to Ameer Abdullah in their victory over the Detroit Lions. Bishiop Sankey also had a big week, so look for that to continue against Cleveland.
General rule: do not start a running back against the St. Louis Rams unless you absolutely have to. Last week it was Marshawn Lynch, a player you have to start every week considering how high you drafted him. Alfred Morris however is not such the case unless you're in a larger than normal league. CJ Anderson's injury seems like it won't keep him off the field, but he definitely will split carries against a tough Kansas City defense.
Wide Receivers:
| Players to Start | Players to Sit | |
| 1 | Kendall Wright @ Cleveland | Jeremy Maclin vs. Denver |
| 2 | Steve Smith @ Oakland | Julian Edelman @ Buffalo |
| 3 | Terrence Williams @ Philadelphia | Amari Cooper vs. Baltimore |
| 4 | Brandon Marshall @ Indianapolis | Andre Johnson vs. New York Jets |
| 5 | Anquan Boldin @ Pittsburgh | Davante Adams vs. Seattle |
Kendall Wright had a solid week against the Buccaneers while Joe Haden and the Cleveland Browns did not look at their sharpest; give him a shot in your flex this week. Steve Smith is probably going to light up a weak Oakland defense after a tough loss last week. Terrence Williams will be a more prominent target for Tony Romo with Dez Bryant out and the Eagles' secondary did not look too tough last week.
Jeremy Maclin was not able to end the more-than-a-year-long streak of the Kansas City Chiefs not having a wide receiver with a touchdown last week. Don't expect that this week either as they face a tough Denver defense with one of the better cornerback tandems in the game. Julian Edelman had a big week against the Steelers, but he won't be able to duplicate it in Buffalo. Normally I would immediately start Andre Johnson when TY Hilton is injured, but that means that Johnson will attract the attention of Darrelle Revis which hurts his stock this week. Davante Adams will suffer from a similar problem as he will probably see receive attention from Seattle's secondary with Jordy Nelson out.