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NFL Odds and Predictions: Picking the full Week 16 slate of games against the spread

We make our picks against the spread and versus the totals for every game on the NFL schedule in Week 16.

NFL: Indianapolis Colts at Pittsburgh Steelers Charles LeClaire-USA TODAY Sports

While the Pittsburgh Steelers rebounded in impressive style last Sunday, it was a feat we could not match with the BTSC staff picks after both of us went 8-7 against the spread and the totals.

Although there are seven road favorites in Week 16, the Steelers are not one of them as 6.5-point underdogs for their matchup with the New Orleans Saints. Six games feature a spread of more than a touchdown, with four contests separated by double-digit lines.

Pittsburgh can clinch a division title with a win over New Orleans and a loss by the Baltimore Ravens (+4) when travelling to face the Los Angeles Chargers on Saturday night. Even if the Ravens win, they can still guarantee themselves of at least a playoff berth in 2018 with a win on Sunday and a loss by both the Indianapolis Colts (-9.5) hosting the New York Giants and a loss by the Tennessee Titans (-10) at home against the Washington Redskins.

Given the relative quality of their opponents, the Steelers’ best chances of receiving some help this weekend rests with the Chargers. Go Bolts!

Selections have been made using the consensus Las Vegas odds from as of Friday night and we encourage you to play along with us by adding your picks below.