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Steelers open as 6.5-point underdogs vs. the Bills in Week 1

The Pittsburgh Steelers will be traveling to Buffalo to start the season, and they are early underdogs in the AFC showdown.

Pittsburgh Steelers v Buffalo Bills Photo by Timothy T Ludwig/Getty Images

The Pittsburgh Steelers are coming off a 2020 regular season where they started 11-0, and fizzled down the stretch. While they did win the AFC North, their one-and-done playoff performance has left fans thinking 2021 could be a let down.

But should they be thinking this?

The Steelers’ 2021 schedule doesn’t give them any breaks as they have the most difficult schedule in the NFL, based on 2020 win percentage. Speaking of the 2021 regular season schedule, it will be announced officially Wednesday night, but the NFL did something they haven’t done in the past, and that is releasing the Week 1 schedule early.

For the Steelers it means a trip to the Buffalo Bills for the second season in a row. On top of that, it is the seventh straight season the Steelers have started the season on the road, they are 3-2-1 in those games. Will it be a repeat performance of last year’s loss in Orchard Park? Or will the Steelers be able to show the NFL world they shouldn’t be taken lightly in 2021?

If Las Vegas has anything to say about it, they would suggest the Steelers might have a tough time against Buffalo again. According to, the Steelers have opened at 6.5-point underdogs vs. the Bills on the road.

Check out the full list of Week 1 odds below:

NFL Week 1 Opening Odds

Thursday, Sept. 9

Cowboys at Buccaneers (-6)

Sunday, Sept. 12

Vikings at Bengals (+2.5)

Steelers at Bills (-6)

Seahawks at Colts (-2.5)

Browns at Chiefs (-5.5)

Eagles at Falcons (-3.5)

Broncos at Giants (Pick ‘Em)

49ers at Lions (+8)

Jets at Panthers (-3.5)

Dolphins at Patriots (-1.5)

Packers at Saints (-3)

Jaguars at Texans (+1.5)

Cardinals at Titans (-1.5)

Chargers at Washington (+1.5)

Bears at Rams (-7)

Monday, Sept. 13

Ravens at Raiders (+6.5)

What do you think about the odds? Do you see the Steelers keeping it close, or possibly even winning the game? Let us know what you think in the comment section below, and be sure to stay tuned to BTSC for the latest news and notes as the team prepares for the 2021 regular season.