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NFL Week 1 Betting Preview: Steelers currently 6.5-point underdogs against the Bills

The Steelers and Bills face off for the third-straight season.

Buffalo Bills vs Pittsburgh Steelers Set Number: X163478

The Pittsburgh Steelers and the Buffalo Bills are facing off to open the 2021 NFL regular season for the first time since 1978. With the Bills getting the best of the Steelers each of the last two seasons, this will be the first time the teams have faced off not in prime time since the Steelers defeated the Bills in 2016. But how do these teams match up this season?

When it comes to the betting lines for Sunday’s game, the following information is the current consensus spread and over/under for the Steelers this week as reported by

Game Info: Week 1

Pittsburgh Steelers vs Buffalo Bills

Sunday, September 12, 2021 at 1:00 PM

Betting line: +6.5

Over/under: 49

Last Regular Season Meeting: Steelers (L) 26-15 at Buffalo

Win streak: 2 game BUF

Last 3 Meetings: PIT 1 - 2 BUF

Last 10 Meetings: PIT 7 - 3 WAS

The opening line on the game was at +6 when the schedule was released in May. This line moved as far as +7 through the preseason before settling in at +6.5 as 53-man rosters were announced.

Coming in as underdogs on Sunday, the Steelers have a current moneyline of +230 to win the game straight up, which is the equivalent of 23/10 odds. So a $20 bet placed on the Steelers over the Bills would have a payout of $66 ($46 plus the original $20 bet). The Bills have a current moneyline of -275, or 4/11 odds. Therefore the same $20 bet placed on Buffalo to win straight up would also have a payout of $27.27 ($7.27 plus the original $20 bet) .

According to, the Steelers are 2-5 against the spread in their last 7 games and are 10-3 against the spread the last 13 games against Buffalo. The Steelers also have gone OVER in 4 of their last 5 games and have gone UNDER in 14 of their last 20 games on the road.

If looking at the futures bets, the Steelers odds to win the Super Bowl are 40/1 after opening at 30/1 during the offseason. The Steelers odds to win the AFC Championship are 20/1 odds. As for winning the AFC North, the Steelers are currently at 4/1 odds and are behind both the Ravens and the Browns at 7/5 odds. The Bengals bring up the rear with 12/1 odds.