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Quarterbacks
- Tom Brady at Dallas
- Matt Ryan vs. Washington
- Aaron Rodgers vs. St. Louis
- Eli Manning vs. San Francisco
- Peyton Manning at Oakland
- Carson Palmer at Detroit
- Drew Brees at Philadelphia
- Sam Bradford vs. New Orleans
- Tyrod Taylor at Tennessee
- Russell Wilson at Cincinnati
- Philip Rivers vs. Pittsburgh
- Andy Dalton vs. Seattle
- Joe Flacco vs. Cleveland
- Michael Vick at San Diego
- Brandon Weeden vs. New England
Be prepared for the Patriots to put up a ton of points against a Cowboys team that seems to take on a new injury every week. New England will be coming off the bye week and is typically strong when doing so, but that also might mean you could make a play for Weeden to go up against a not-so-great Patriots' defense if you are suffering from quarterback injury blues this week. Eli Manning is usually not so high up, but his three touchdown performance last week is a good sign that the Giants' offense is improving and now it gets to face a struggling 49ers defense.
Running Backs
- Le'Veon Bell at San Diego
- Jamaal Charles vs. Chicago
- Devonta Freeman vs. Washington
- Justin Forsett vs. Cleveland
- Matt Forte at Kansas City
- Arian Foster vs. Indianapolis
- Eddie Lacy vs. St. Louis
- Todd Gurley at Green Bay
- Mark Ingram at Philadelphia
- T.J. Yeldon at Tampa Bay
- Dion Lewis at Dallas
- Joseph Randle vs. New England
- Ronnie Hillman at Oakland
- Rashad Jennings vs. San Francisco
- Carlos Hyde at New York Giants
Devonta Freeman is on a serious tear this season, especially after his three touchdown performance against the Houston Texans last week. Justin Forsett's 150 yard performance against Pittsburgh was a good sign of a possible resurgence for fantasy owners who have been disappointed in Forsett's performance so far this season. Lacy is still a must start, but do not be surprised to see him with a lot less points this week against the Rams' defensive front. Arian Foster is a player that needs to be a starter for his game tonight, though his 2015 debut was anything but spectacular, he will be a much bigger player in the offense this week against a Colts team that struggled to stop T.J. Yeldon last week.
Yeldon is another player you should give a look against Tampa Bay. His performance last week could be the lean that fantasy owners have been looking for so that he can get a larger majority of the carries over Toby Gerhardt. Surprise picks this week should be Ronnie Hillman and Rashad Jennings. Hillman is taking more snaps as the starter and could be a great FLEX option this week, but Jennings is going to get to join in on the fun against the 49ers defense that can't seem to stop anybody after it's dominating performance against Adrian Peterson and the Vikings in week one.
Wide Receivers
- Julio Jones vs. Washington
- Odell Bekcham Jr. vs. San Francisco
- Antonio Brown at San Diego
- Demaryius Thomas at Oakland
- Julian Edelman at Dallas
- Randall Cobb vs. St. Louis
- Larry Fitzgerald at Detroit
- Jeremy Maclin vs. Chicago
- DeAndre Hopkins vs. Indianapolis
- Emmanuel Sanders at Oakland
- AJ Green vs. Seattle
- Calvin Johnson vs. Arizona
- Keenan Allen vs. Pittsburgh
- Allen Robinson at Tampa Bay
- Mike Evans vs. Jacksonville
- James Jones vs. St. Louis
- Rueben Randle vs. San Francisco
- Jordan Matthews vs. New Orleans
- Travis Benjamin at Baltimore
- Martavis Bryant at San Diego
Rueben Randle is starting to benefit from the absence of Victor Cruz and while the 49ers will be too busy trying to keep up Beckham Jr., he will certainly get some opportunities to get on the scoreboard. Though the Packers face the Rams' defense and James Jones is on the injury report, he deserves a nod this week as Aaron Rodgers will be looking to capitalize on the Rams' secondary. Martavis Bryant may be just seeing his first appearance of 2015, but his deep threat ability combined with Vick's arm strength could be a recipe for disaster against the Chargers as they try to contain Le'Veon Bell.